Endocrine Abstracts

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patient’s well-being worsened sharply. The laboratory examination revealed...

Introduction: Parathyroid carcinoma (PC) is one of the rarest endocrine malignancies. Most PCs are sporadic, sometimes occurring in the framework of familial primary hyperparathyroidism (PHPT). PHPT due to PC is usually characterized by significantly increased PTH levels, severe hypercalcemia, larger tumor size and a higher incidence of disease complications. Clinical case: A 56-year-old male C. presented with an accidental formation at the posterior con...

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...

Background: Atypical parathyroid tumor (APT) generally has a better prognosis compared to parathyroid carcinoma (PC). The differential diagnosis of APT and PC is crucial for further management. Diagnosis of both is based on morphological examination but sometimes can be challenging. In such cases immunohistochemistry (IHC) should be used.Objective: To estimate the utility of IHC in the differential diagnosis of APT and PC.Materials...

Hypoparathyroidism (HPT) is the most common autoimmune endocrine involvement of APECED syndrome (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, 79-96% cases). HPT is associated with reduced bone remodeling, abnormalities in microarchitecture and bone strength, thus low-energy fractures occur despite normal or even high bone mineral density (BMD). Other APECED components (hypogonadism, malabsorption, growth hormone deficiency etc.), may also affect bone metabol...

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN-1) is an autosomal dominant disorder caused by germline mutations in the MEN1 gene encoding menin. MEN1 mutations are mainly represented by deletions/insertions, nonsense, splice site or missense mutations and can be detected by DNA sequencing. MEN-1 generally includes parathyroid, adenohypophysis, and pancreatoduodenal neuroendocrine tumors.Clinical Case: Patient S., 26-ye...

Introduction: Parathyroid carcinoma (PC) is one of the rarest malignant endocrine neoplasms (0.005% of all oncological diseases). PC relapses in 40-60% cases. The severity of the disease is determined by life-threatening hypercalcemia. Surgery is the gold treatment standard of primary tumors and distant metastases, but if it is contraindicated there are few options to control life-threatening hypercalcemia.Case 1: A 36-year-old-woman with a recurrent par...

Introduction: Over the last decades, there has been a significant increase in the incidence of thyroid cancer. Papillary thyroid cancer (PTC) is the most common histopathological type with often a favorable prognosis. Conventional therapies include surgical resection, adjuvant therapy with radioactive iodine, and suppressive therapy with thyroid hormones. However, the prognosis for iodine-resistant/refractory thyroid cancers or the advanced metastatic cancer is less favorable....